Curative and β cell regenerative effects of α1-antitrypsin treatment in autoimmune diabetic NOD mice

Invasive insulitis is a destructive T cell-dependent autoimmune process directed against insulin-producing β cells that is central to the pathogenesis of type 1 diabetes mellitus (T1DM) in humans and the clinically relevant nonobese diabetic (NOD) mouse model. Few therapies have succeeded in restori...

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Main Authors: Koulmanda, Maria, Bhasin, Manoj, Hoffman, Lauren, Fan, Zhigang, Qipo, Andi, Shi, Hang, Bonner-Weir, Susan, Putheti, Prabhakar, Degauque, Nicolas, Libermann, Towia A., Auchincloss, Hugh, Flier, Jeffrey S., Strom, Terry B.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2008
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570971/
https://ncbi.nlm.nih.gov/pubmed/18852471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0808031105
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