Potent Inhibition and Global Co-localization Implicate the Transmembrane Kunitz-type Serine Protease Inhibitor Hepatocyte Growth Factor Activator Inhibitor-2 in the Regulation of Epithelial Matriptase Activity

Hepatocyte growth factor activator inhibitors (HAI)-1 and -2 are recently identified and closely related Kunitz-type transmembrane serine protease inhibitors. Whereas HAI-1 is well established as an inhibitor of the serine proteases matriptase and hepatocyte growth factor activator, the physiologica...

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Main Authors: Szabo, Roman, Hobson, John P., List, Karin, Molinolo, Alfredo, Lin, Chen-Yong, Bugge, Thomas H.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Enzyme Catalysis and Regulation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570866/
https://ncbi.nlm.nih.gov/pubmed/18713750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801970200
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