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Unexpected Activity of a Novel Kunitz-type Inhibitor: INHIBITION OF CYSTEINE PROTEASES BUT NOT SERINE PROTEASES

Kunitz-type (KT) protease inhibitors are low molecular weight proteins classically defined as serine protease inhibitors. We identified a novel secreted KT inhibitor associated with the gut and parenchymal tissues of the infective juvenile stage of Fasciola hepatica, a helminth parasite of medical a...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Smith, David, Tikhonova, Irina G., Jewhurst, Heather L., Drysdale, Orla C., Dvořák, Jan, Robinson, Mark W., Cwiklinski, Krystyna, Dalton, John P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016662/
https://ncbi.nlm.nih.gov/pubmed/27422822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.724344
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