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Internal Azomethine Ylide Cycloaddition Methodology for Access to the Substitution Pattern of Aziridinomitosene A

[Image: see text] Highly substituted, tethered alkyne dipolarophiles participate in the internal 2 + 3 cycloaddition with azomethine ylides generated by treatment of oxazolium salts with cyanide ion. Starting from oxazole 26, a sequence of N-methylation, cyanide addition, and electrocyclic ring open...

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Main Authors: Bobeck, Drew R., Warner, Don L., Vedejs, Edwin
Formato: Artigo
Idioma:Inglês
Publicado: 2007
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570649/
https://ncbi.nlm.nih.gov/pubmed/17910499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo7013559
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