GSTP1 Ile105Val polymorphism correlates with progression-free survival in MCRC patients treated with or without irinotecan: a study of the Dutch Colorectal Cancer Group

A Valine residue at position 105 of the GSTP1 protein results in decreased enzyme activity. As nuclear GSTP1 activity decreases irinotecan cytotoxicity, Val-allele carriers may benefit more from irinotecan chemotherapy. Our aim was to investigate the association of GSTP1 genotype with treatment outc...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Kweekel, D M, Koopman, M, Antonini, N F, Van der Straaten, T, Nortier, J W R, Gelderblom, H, Punt, C J A, Guchelaar, H-J
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2008
Teme:
Genetics and Genomics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570506/
https://ncbi.nlm.nih.gov/pubmed/18797455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604654
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki