GSTP1 Ile105Val polymorphism correlates with progression-free survival in MCRC patients treated with or without irinotecan: a study of the Dutch Colorectal Cancer Group

A Valine residue at position 105 of the GSTP1 protein results in decreased enzyme activity. As nuclear GSTP1 activity decreases irinotecan cytotoxicity, Val-allele carriers may benefit more from irinotecan chemotherapy. Our aim was to investigate the association of GSTP1 genotype with treatment outc...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Kweekel, D M, Koopman, M, Antonini, N F, Van der Straaten, T, Nortier, J W R, Gelderblom, H, Punt, C J A, Guchelaar, H-J
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2008
Schlagworte:
Genetics and Genomics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570506/
https://ncbi.nlm.nih.gov/pubmed/18797455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604654
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