PCLO Variants Are Nominally Associated With Early-Onset Type 2 Diabetes and Insulin Resistance in Pima Indians

OBJECTIVE—A prior genome-wide association (GWA) study in Pima Indians identified variants within PCLO that were associated with early-onset type 2 diabetes. PCLO encodes a presynaptic cytomatrix protein that functions as a Ca(2+) sensor that may be involved in insulin secretion and/or insulin action...

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Autors principals: Ma, Lijun, Hanson, Robert L., Que, Lorem N., Guo, Yan, Kobes, Sayuko, Bogardus, Clifton, Baier, Leslie J.
Format: Artigo
Idioma:Inglês
Publicat: American Diabetes Association 2008
Matèries:
Genetics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570415/
https://ncbi.nlm.nih.gov/pubmed/18647954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db07-1800
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