Cytokine-Induced β-Cell Death Is Independent of Endoplasmic Reticulum Stress Signaling

OBJECTIVE—Cytokines contribute to β-cell destruction in type 1 diabetes. Endoplasmic reticulum (ER) stress–mediated apoptosis has been proposed as a mechanism for β-cell death. We tested whether ER stress was necessary for cytokine-induced β-cell death and also whether ER stress gene activation was...

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Main Authors: Åkerfeldt, Mia C., Howes, Jennifer, Chan, Jeng Yie, Stevens, Veronica A., Boubenna, Nacer, McGuire, Helen M., King, Cecile, Biden, Trevor J., Laybutt, D. Ross
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2008
Assuntos:
Islet Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570400/
https://ncbi.nlm.nih.gov/pubmed/18591394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db07-1802
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