Lack of FFAR1/GPR40 Does Not Protect Mice From High-Fat Diet–Induced Metabolic Disease

OBJECTIVE—FFAR1/GPR40 is a G-protein–coupled receptor expressed predominantly in pancreatic islets mediating free fatty acid–induced insulin secretion. However, the physiological role of FFAR1 remains controversial. It was previously reported that FFAR1 knockout (Ffar1(−/−)) mice were resistant to h...

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Main Authors: Lan, Hong, Hoos, Lizbeth M., Liu, Li, Tetzloff, Glen, Hu, Weiwen, Abbondanzo, Susan J., Vassileva, Galya, Gustafson, Eric L., Hedrick, Joseph A., Davis, Harry R.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Diabetes Association 2008
נושאים:
Obesity Studies
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570396/
https://ncbi.nlm.nih.gov/pubmed/18678612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-0596
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