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Identification of an Orally Efficacious GPR40/FFAR1 Receptor Agonist

[Image: see text] GPR40/FFAR1 is a G protein-coupled receptor predominantly expressed in pancreatic β-cells and activated by long-chain free fatty acids, mediating enhancement of glucose-stimulated insulin secretion. A novel series of substituted 3-(4-aryloxyaryl)propanoic acid derivatives were prep...

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Vydáno v:ACS Med Chem Lett
Hlavní autoři: Agarwal, Sameer, Sasane, Santosh, Deshmukh, Prashant, Rami, Bhadresh, Bandyopadhyay, Debdutta, Giri, Poonam, Giri, Suresh, Jain, Mukul, Desai, Ranjit C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2016
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5150676/
https://ncbi.nlm.nih.gov/pubmed/27994752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00331
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