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Identification of an Orally Efficacious GPR40/FFAR1 Receptor Agonist
[Image: see text] GPR40/FFAR1 is a G protein-coupled receptor predominantly expressed in pancreatic β-cells and activated by long-chain free fatty acids, mediating enhancement of glucose-stimulated insulin secretion. A novel series of substituted 3-(4-aryloxyaryl)propanoic acid derivatives were prep...
Gardado en:
| Publicado en: | ACS Med Chem Lett |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Chemical
Society
2016
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5150676/ https://ncbi.nlm.nih.gov/pubmed/27994752 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00331 |
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