Mammary Epithelial-Specific Disruption of Focal Adhesion Kinase Retards Tumor Formation and Metastasis in a Transgenic Mouse Model of Human Breast Cancer

Focal adhesion kinase (FAK) is a central regulator of the focal adhesion, influencing cell proliferation, survival, and migration. Despite evidence demonstrating FAK overexpression in human cancer, its role in tumor initiation and progression is not well understood. Using Cre/LoxP technology to spec...

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Detaylı Bibliyografya
Asıl Yazarlar: Provenzano, Paolo P., Inman, David R., Eliceiri, Kevin W., Beggs, Hilary E., Keely, Patricia J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Investigative Pathology 2008
Konular:
Regular Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570144/
https://ncbi.nlm.nih.gov/pubmed/18845837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2008.080308
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