Adenoviral Overexpression and Small Interfering RNA Suppression Demonstrate That Plasminogen Activator Inhibitor-1 Produces Elevated Collagen Accumulation in Normal and Keloid Fibroblasts

Keloids are tumor-like skin scars that grow as a result of the aberrant healing of skin injuries, with no effective treatment. We provide new evidence that both overexpression of plasminogen activator inhibitor-1 (PAI-1) and elevated collagen accumulation are intrinsic features of keloid fibroblasts...

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Detalhes bibliográficos
Principais autores: Tuan, Tai-Lan, Hwu, Paul, Ho, Wendy, Yiu, Peter, Chang, Richard, Wysocki, Annette, Benya, Paul D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2008
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570122/
https://ncbi.nlm.nih.gov/pubmed/18832570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2008.080272
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