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Computational Studies of the Farnesyltransferase Ternary Complex Part II: The Conformational Activation of Farnesyldiphosphate

Studies aimed at elucidating the reaction mechanism of farnesyltransferase (FTase), which catalyzes the prenylation of many cellular signaling proteins including Ras, has been an active area of research. Much is known regarding substrate binding and the impact of various catalytic site residues on c...

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Bibliografiske detaljer
Main Authors: Cui, Guanglei, Merz, Kenneth M.
Format: Artigo
Sprog:Inglês
Udgivet: 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570014/
https://ncbi.nlm.nih.gov/pubmed/17918965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi701324t
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