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Finding a Needle in the Haystack: Computational Modeling of Mg(2+) Binding in the Active Site of Protein Farnesyltransferase
Studies aimed at elucidating the unknown Mg(2+) binding site in protein farnesyltransferase (FTase) are reported. FTase catalyzes the transfer of a farnesyl group to a conserved cysteine residue (Cys1p) on a target protein, an important step for proteins in the signal transduction pathways (e.g. Ras...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3035748/ https://ncbi.nlm.nih.gov/pubmed/20923173 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi1008358 |
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