Nuclear Akt interacts with B23/NPM and protects it from proteolytic cleavage, enhancing cell survival

B23/NPM is a major nucleolar phosphoprotein that has a critical role in cell proliferation and cell death. Here, we show that it forms a complex with Akt on growth factor (GF) stimulation in both the cytoplasm and the nucleus, for which Akt activation is indispensable. The C terminus of B23 (239–294...

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Bibliografiske detaljer
Main Authors: Lee, Sang Bae, Xuan Nguyen, Truong L., Choi, Joung Woo, Lee, Kyung-Hoon, Cho, Sung-Woo, Liu, Zhixue, Ye, Keqiang, Bae, Sun Sik, Ahn, Jee-Yin
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2008
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2569968/
https://ncbi.nlm.nih.gov/pubmed/18931307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0807668105
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