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Nuclear Akt interacts with B23/NPM and protects it from proteolytic cleavage, enhancing cell survival
B23/NPM is a major nucleolar phosphoprotein that has a critical role in cell proliferation and cell death. Here, we show that it forms a complex with Akt on growth factor (GF) stimulation in both the cytoplasm and the nucleus, for which Akt activation is indispensable. The C terminus of B23 (239–294...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2569968/ https://ncbi.nlm.nih.gov/pubmed/18931307 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0807668105 |
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