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Akt phosphorylates acinus and inhibits its proteolytic cleavage, preventing chromatin condensation
Akt promotes cell survival by phosphorylating and inhibiting components of the intrinsic cell death machinery. Akt translocates into the nucleus upon exposure of cells to survival factors, but little is known about its functions in the nucleus. Here, we show that acinus, a nuclear factor required fo...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1276706/ https://ncbi.nlm.nih.gov/pubmed/16177823 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600823 |
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