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Transcription Increases Methylmethane Sulfonate-Induced Mutations in alkB Strains of Escherichia coli
Methylmethane sulfonate (MMS) produces DNA base lesions, including 3-methylcytosine (m3C), more effectively in single-stranded DNA. The repair of m3C in Escherichia coli is mediated by AlkB through oxidative demethylation and in the absence of repair, m3C leads to base-substitution mutations. We des...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2008
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2569841/ https://ncbi.nlm.nih.gov/pubmed/18515192 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2008.04.008 |
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