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Kinetic studies of Escherichia coli AlkB using a new fluorescence-based assay for DNA demethylation

The Escherichia coli AlkB protein catalyzes the direct reversal of alkylation damage to DNA; primarily 1-methyladenine (1mA) and 3-methylcytosine (3mC) lesions created by endogenous or environmental alkylating agents. AlkB is a member of the non-heme iron (II) α-ketoglutarate-dependent dioxygenase s...

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Bibliografiske detaljer
Main Authors: Roy, Todd W., Bhagwat, A. S.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2175350/
https://ncbi.nlm.nih.gov/pubmed/18003660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm1031
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