Synthesis of (2'-5')oligoadenylate and activation of an endoribonuclease in interferon-treated HeLa cells infected with reovirus.

Treatment with interferon protected HeLa cells from infection with reovirus. This virus apparently activated an antiviral mechanism that was detected by the presence of (2'-5')oligoadenylate [(2'-5')An] in intact cells. The (2'-5')An was previously shown to activate an endoribonuclease, RNase L. We...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Nilsen, T W, Maroney, P A, Baglioni, C
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1982
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC256937/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6178844/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.42.3.1039-1045.1982
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