Synthesis of (2'-5')oligoadenylate and activation of an endoribonuclease in interferon-treated HeLa cells infected with reovirus.

Treatment with interferon protected HeLa cells from infection with reovirus. This virus apparently activated an antiviral mechanism that was detected by the presence of (2'-5')oligoadenylate [(2'-5')An] in intact cells. The (2'-5')An was previously shown to activate an endoribonuclease, RNase L. We...

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Bibliografische gegevens

Gepubliceerd in:	J Virol
Hoofdauteurs:	Nilsen, T W, Maroney, P A, Baglioni, C
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	American Society for Microbiology (ASM) 1982
Onderwerpen:	Research Article
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC256937/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6178844/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.42.3.1039-1045.1982
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