N(5)-CAIR Mutase: the role of a CO(2) binding site and substrate movement in catalysis

N(5)-Carboxyaminoimidazole ribonucleotide mutase (N(5)-CAIR mutase or PurE) from Escherichia coli catalyzes the reversible interconversion of N(5)-CAIR to carboxyaminoimidazole ribonucleotide (CAIR) with direct CO(2) transfer. Site-directed mutagenesis, a pH rate profile, DFT calculations, and X-ray...

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Hlavní autoři: Hoskins, Aaron A., Morar, Mariya, Kappock, T. Joseph, Mathews, Irimpan I., Zaugg, Judith B., Barder, Timothy E., Peng, Paul, Okamoto, Akimitsu, Ealick, Steven E., Stubbe, JoAnne
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2569195/
https://ncbi.nlm.nih.gov/pubmed/17298082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi602436g
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