Activation of natural regulatory T cells by IgG Fc–derived peptide “Tregitopes”

We have identified at least 2 highly promiscuous major histocompatibility complex class II T-cell epitopes in the Fc fragment of IgG that are capable of specifically activating CD4(+)CD25(Hi)FoxP3(+) natural regulatory T cells (nT(Regs)). Coincubation of these regulatory T-cell epitopes or “Tregitop...

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Detalles Bibliográficos
Main Authors: De Groot, Anne S., Moise, Leonard, McMurry, Julie A., Wambre, Erik, Van Overtvelt, Laurence, Moingeon, Philippe, Scott, David W., Martin, William
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2008
Assuntos:
Immunobiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2569179/
https://ncbi.nlm.nih.gov/pubmed/18660382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-02-138073
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