In Vitro and In Vivo Studies of IgG-derived Treg Epitopes (Tregitopes): A Promising New Tool for Tolerance Induction and Treatment of Autoimmunity

Tregitopes are regulatory T cell epitopes derived from immunoglobulin G (IgG) that stimulate CD25(+) FoxP3(+) T cells to expand. In conjunction with these Tregs, Tregitopes can prevent, treat, and even cure autoimmune disease in mouse models, suppress allo-specific responses in murine transplant mod...

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Detalhes bibliográficos
Main Authors: Cousens, Leslie P., Najafian, Nader, Mingozzi, Federico, Elyaman, Wassim, Mazer, Bruce, Moise, Leonard, Messitt, Timothy J., Su, Yan, Sayegh, Mohamed, High, Katherine, Khoury, Samia J., Scott, David W., De Groot, Anne S.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3538121/
https://ncbi.nlm.nih.gov/pubmed/22941509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10875-012-9762-4
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