Development of regulatory T cells requires IL-7Rα stimulation by IL-7 or TSLP

Interleukin-7 (IL-7), a cytokine produced by stromal cells, is required for thymic development and peripheral homeostasis of most major subsets of T cells. We examined whether regulatory T (Treg) cells also required the IL-7 pathway by analyzing IL-7Rα(−/−) mice. We observed a striking reduction in...

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Main Authors: Mazzucchelli, Renata, Hixon, Julie A., Spolski, Rosanne, Chen, Xin, Li, Wen Qing, Hall, Veronica L., Willette-Brown, Jami, Hurwitz, Arthur A., Leonard, Warren J., Durum, Scott K.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society of Hematology 2008
Ábhair:
Immunobiology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2569178/
https://ncbi.nlm.nih.gov/pubmed/18664628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-02-137414
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