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The influence of IL-2 family cytokines on activation and function of naturally occurring regulatory T cells
IL-2 is essential for CD4+CD25+forkhead box P3+ (FoxP3+) naturally occurring regulatory T cell (Treg) homeostasis and activation. Binding of IL-2 to its receptor leads to phosphorylation of STAT5, and binding of phosphorylated STAT5 to the foxp3 promoter increases foxp3 transcription, resulting in e...
Tallennettuna:
| Päätekijät: | , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
The Society for Leukocyte Biology
2008
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2538590/ https://ncbi.nlm.nih.gov/pubmed/18653463 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.1107778 |
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