The influence of IL-2 family cytokines on activation and function of naturally occurring regulatory T cells

IL-2 is essential for CD4+CD25+forkhead box P3+ (FoxP3+) naturally occurring regulatory T cell (Treg) homeostasis and activation. Binding of IL-2 to its receptor leads to phosphorylation of STAT5, and binding of phosphorylated STAT5 to the foxp3 promoter increases foxp3 transcription, resulting in e...

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Bibliographic Details
Main Authors: Wuest, Thomas Y., Willette-Brown, Jami, Durum, Scott K., Hurwitz, Arthur A.
Format: Artigo
Language:Inglês
Published: The Society for Leukocyte Biology 2008
Subjects:
NCI Cancer and Inflammation Conference, October 9-10, 2007, Bethesda, Maryland
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2538590/
https://ncbi.nlm.nih.gov/pubmed/18653463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.1107778
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