Identification and Functional Characterization of an N-terminal Oligomerization Domain for Polycystin-2

Autosomal dominant polycystic kidney disease (ADPKD), the most common inherited cause of kidney failure, is caused by mutations in either PKD1 (85%) or PKD2 (15%). The PKD2 protein, polycystin-2 (PC2 or TRPP2), is a member of the transient receptor potential (TRP) superfamily and functions as a non-...

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Autors principals: Feng, Shuang, Okenka, Genevieve M., Bai, Chang-Xi, Streets, Andrew J., Newby, Linda J., DeChant, Brett T., Tsiokas, Leonidas, Obara, Tomoko, Ong, Albert C. M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2008
Matèries:
Molecular Basis of Cell and Developmental Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2568912/
https://ncbi.nlm.nih.gov/pubmed/18701462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803834200
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