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Leptin Stimulates Both JAK2-dependent and JAK2-independent Signaling Pathways
Leptin controls body weight by activating the long form of the leptin receptor (LEPRb). Janus kinase 2 (JAK2) is associated with LEPRb and autophosphorylates in response to leptin. JAK2 also phosphorylates LEPRb, STAT3, and multiple other downstream molecules. Surprisingly, here we show that JAK2 is...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2568905/ https://ncbi.nlm.nih.gov/pubmed/18718905 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805545200 |
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