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Efficient Solid-Phase Synthesis of 2-Substituted-3-Hydroxy-4(1H)-Quinolinone-7-Carboxamides with Two Diversity Positions
Highly efficient solid-phase synthesis of 2-substituted-3-hydroxy-4(1H)-quinolinone-7-carboxamides was developed using anthranilates and bromoketones as the key synthons. Primary amines immobilized to acid-cleavable BAL linker were acylated with 1-methyl-2-aminoterephtalate. Following cleavage of th...
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| Autors principals: | , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2007
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2568080/ https://ncbi.nlm.nih.gov/pubmed/17676809 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cc070071v |
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