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Efficient Solid-Phase Synthesis of 2-Substituted-3-Hydroxy-4(1H)-Quinolinone-7-Carboxamides with Two Diversity Positions

Highly efficient solid-phase synthesis of 2-substituted-3-hydroxy-4(1H)-quinolinone-7-carboxamides was developed using anthranilates and bromoketones as the key synthons. Primary amines immobilized to acid-cleavable BAL linker were acylated with 1-methyl-2-aminoterephtalate. Following cleavage of th...

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Detalhes bibliográficos
Main Authors: Soural, Miroslav, Krchňák, Viktor
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2568080/
https://ncbi.nlm.nih.gov/pubmed/17676809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cc070071v
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