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Efficient Solid-Phase Synthesis of 3-Substituted-5-Oxo-5H-Thiazolo[2,3-b]Quinazoline-8-Carboxamide under Mild Conditions with Two Diversity Positions

Highly efficient solid-phase synthesis of thiazolo[2,3,b]quinazolines under mild conditions was developed using resin-bound 2-amino-terephthalamic acid, Fmoc-NCS, and bromoketones. Primary amines immobilized to an acid-cleavable backbone amide linker were acylated with 1-methyl-2-aminoterephtalate....

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Detalhes bibliográficos
Main Authors: Bouillon, Isabelle, Krchňák, Viktor
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2569825/
https://ncbi.nlm.nih.gov/pubmed/17907790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cc700122a
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