Identification of a new JNK inhibitor targeting the JNK-JIP interaction site

JNK is a stress-activated protein kinase that modulates pathways implicated in a variety of disease states. JNK-interacting protein-1 (JIP1) is a scaffolding protein that enhances JNK signaling by creating a proximity effect between JNK and upstream kinases. A minimal peptide region derived from JIP...

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Bibliografiske detaljer
Main Authors: Stebbins, John L., De, Surya K., Machleidt, Thomas, Becattini, Barbara, Vazquez, Jesus, Kuntzen, Christian, Chen, Li-Hsing, Cellitti, Jason F., Riel-Mehan, Megan, Emdadi, Aras, Solinas, Giovanni, Karin, Michael, Pellecchia, Maurizio
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2008
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2567907/
https://ncbi.nlm.nih.gov/pubmed/18922779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805677105
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