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Mammalian Transcription Factor ATF6 Is Synthesized as a Transmembrane Protein and Activated by Proteolysis in Response to Endoplasmic Reticulum Stress

The unfolded protein response (UPR) controls the levels of molecular chaperones and enzymes involved in protein folding in the endoplasmic reticulum (ER). We recently isolated ATF6 as a candidate for mammalian UPR-specific transcription factor. We report here that ATF6 constitutively expressed as a...

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Bibliografiske detaljer
Main Authors: Haze, Kyosuke, Yoshida, Hiderou, Yanagi, Hideki, Yura, Takashi, Mori, Kazutoshi
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Cell Biology 1999
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC25679/
https://ncbi.nlm.nih.gov/pubmed/10564271
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