Human sperm devoid of PLC, zeta 1 fail to induce Ca(2+) release and are unable to initiate the first step of embryo development

Egg activation, which is the first step in the initiation of embryo development, involves both completion of meiosis and progression into mitotic cycles. In mammals, the fertilizing sperm delivers the activating signal, which consists of oscillations in free cytosolic Ca(2+) concentration ([Ca(2+)](...

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Autors principals: Yoon, Sook-Young, Jellerette, Teru, Salicioni, Ana Maria, Lee, Hoi Chang, Yoo, Myung-sik, Coward, Kevin, Parrington, John, Grow, Daniel, Cibelli, Jose B., Visconti, Pablo E., Mager, Jesse, Fissore, Rafael A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2008
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2567839/
https://ncbi.nlm.nih.gov/pubmed/18924610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI36942
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