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Human sperm devoid of PLC, zeta 1 fail to induce Ca(2+) release and are unable to initiate the first step of embryo development

Egg activation, which is the first step in the initiation of embryo development, involves both completion of meiosis and progression into mitotic cycles. In mammals, the fertilizing sperm delivers the activating signal, which consists of oscillations in free cytosolic Ca(2+) concentration ([Ca(2+)](...

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Detalhes bibliográficos
Main Authors: Yoon, Sook-Young, Jellerette, Teru, Salicioni, Ana Maria, Lee, Hoi Chang, Yoo, Myung-sik, Coward, Kevin, Parrington, John, Grow, Daniel, Cibelli, Jose B., Visconti, Pablo E., Mager, Jesse, Fissore, Rafael A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2567839/
https://ncbi.nlm.nih.gov/pubmed/18924610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI36942
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