Selective expansion of a subset of exhausted CD8 T cells by αPD-L1 blockade

Programmed death-1 (PD-1) regulates T cell exhaustion during chronic infections. Blocking the PD-1:PD-ligand (PD-L) pathway reinvigorates exhausted CD8 T cells. Exactly how blocking PD-1:PD-L interactions improves T cell immunity, however, remains unclear. PD-1:PD-L blockade could reprogram all exha...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Blackburn, Shawn D., Shin, Haina, Freeman, Gordon J., Wherry, E. John
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2008
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2567485/
https://ncbi.nlm.nih.gov/pubmed/18809920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0801497105
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk