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Selective expansion of a subset of exhausted CD8 T cells by αPD-L1 blockade
Programmed death-1 (PD-1) regulates T cell exhaustion during chronic infections. Blocking the PD-1:PD-ligand (PD-L) pathway reinvigorates exhausted CD8 T cells. Exactly how blocking PD-1:PD-L interactions improves T cell immunity, however, remains unclear. PD-1:PD-L blockade could reprogram all exha...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2567485/ https://ncbi.nlm.nih.gov/pubmed/18809920 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0801497105 |
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