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CTLA-4 blockade increases IFNγ-producing CD4(+)ICOS(hi) cells to shift the ratio of effector to regulatory T cells in cancer patients
Significant anti-tumor responses have been reported in a small subset of cancer patients treated with the immunotherapeutic agent anti-CTLA-4 antibody. All clinical trials to date, comprising over 3,000 patients, have been conducted in the metastatic disease setting, which allows for correlation of...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2567480/ https://ncbi.nlm.nih.gov/pubmed/18818309 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806075105 |
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