CTLA-4 blockade increases IFNγ-producing CD4(+)ICOS(hi) cells to shift the ratio of effector to regulatory T cells in cancer patients

Significant anti-tumor responses have been reported in a small subset of cancer patients treated with the immunotherapeutic agent anti-CTLA-4 antibody. All clinical trials to date, comprising over 3,000 patients, have been conducted in the metastatic disease setting, which allows for correlation of...

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Detalhes bibliográficos
Main Authors: Liakou, Chrysoula I., Kamat, Ashish, Tang, Derek Ng, Chen, Hong, Sun, Jingjing, Troncoso, Patricia, Logothetis, Christopher, Sharma, Padmanee
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2567480/
https://ncbi.nlm.nih.gov/pubmed/18818309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806075105
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