Upregulated HSP27 in human breast cancer cells reduces Herceptin susceptibility by increasing Her2 protein stability

BACKGROUND: Elucidating the molecular mechanisms by which tumors become resistant to Herceptin is critical for the treatment of Her2-overexpressed metastatic breast cancer. METHODS: To further understand Herceptin resistance mechanisms at the molecular level, we used comparative proteome approaches...

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Hoofdauteurs: Kang, Se Hun, Kang, Keon Wook, Kim, Kyung-Hee, Kwon, Bumi, Kim, Seok-Ki, Lee, Ho-Young, Kong, Sun-Young, Lee, Eun Sook, Jang, Sang-Geun, Yoo, Byong Chul
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2008
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2567332/
https://ncbi.nlm.nih.gov/pubmed/18834540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-8-286
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