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p53-independent mechanisms regulate the P2-MDM2 promoter in adult astrocytic tumours
The MDM2 gene is amplified and/or overexpressed in about 10% of glioblastomas and constitutes one of a number of ways the p53 pathway is disrupted in these tumours. MDM2 encodes a nuclear phosphoprotein that regulates several cell proteins by binding and/or ubiquitinating them, with p53 being a well...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2567066/ https://ncbi.nlm.nih.gov/pubmed/18781178 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604643 |
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