Inversion of allosteric effect of arginine on N-acetylglutamate synthase, a molecular marker for evolution of tetrapods

BACKGROUND: The efficient conversion of ammonia, a potent neurotoxin, into non-toxic metabolites was an essential adaptation that allowed animals to move from the aquatic to terrestrial biosphere. The urea cycle converts ammonia into urea in mammals, amphibians, turtles, snails, worms and many aquat...

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Main Authors: Haskins, Nantaporn, Panglao, Maria, Qu, Qiuhao, Majumdar, Himani, Cabrera-Luque, Juan, Morizono, Hiroki, Tuchman, Mendel, Caldovic, Ljubica
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2008
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2566978/
https://ncbi.nlm.nih.gov/pubmed/18801197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2091-9-24
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