Inversion of allosteric effect of arginine on N-acetylglutamate synthase, a molecular marker for evolution of tetrapods

BACKGROUND: The efficient conversion of ammonia, a potent neurotoxin, into non-toxic metabolites was an essential adaptation that allowed animals to move from the aquatic to terrestrial biosphere. The urea cycle converts ammonia into urea in mammals, amphibians, turtles, snails, worms and many aquat...

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Hlavní autoři: Haskins, Nantaporn, Panglao, Maria, Qu, Qiuhao, Majumdar, Himani, Cabrera-Luque, Juan, Morizono, Hiroki, Tuchman, Mendel, Caldovic, Ljubica
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2008
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2566978/
https://ncbi.nlm.nih.gov/pubmed/18801197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2091-9-24
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