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Inversion of allosteric effect of arginine on N-acetylglutamate synthase, a molecular marker for evolution of tetrapods

BACKGROUND: The efficient conversion of ammonia, a potent neurotoxin, into non-toxic metabolites was an essential adaptation that allowed animals to move from the aquatic to terrestrial biosphere. The urea cycle converts ammonia into urea in mammals, amphibians, turtles, snails, worms and many aquat...

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Detalhes bibliográficos
Main Authors: Haskins, Nantaporn, Panglao, Maria, Qu, Qiuhao, Majumdar, Himani, Cabrera-Luque, Juan, Morizono, Hiroki, Tuchman, Mendel, Caldovic, Ljubica
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2566978/
https://ncbi.nlm.nih.gov/pubmed/18801197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2091-9-24
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