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Inversion of allosteric effect of arginine on N-acetylglutamate synthase, a molecular marker for evolution of tetrapods

BACKGROUND: The efficient conversion of ammonia, a potent neurotoxin, into non-toxic metabolites was an essential adaptation that allowed animals to move from the aquatic to terrestrial biosphere. The urea cycle converts ammonia into urea in mammals, amphibians, turtles, snails, worms and many aquat...

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Autors principals: Haskins, Nantaporn, Panglao, Maria, Qu, Qiuhao, Majumdar, Himani, Cabrera-Luque, Juan, Morizono, Hiroki, Tuchman, Mendel, Caldovic, Ljubica
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2566978/
https://ncbi.nlm.nih.gov/pubmed/18801197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2091-9-24
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