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Protein–DNA interactions: structural, thermodynamic and clustering patterns of conserved residues in DNA-binding proteins

Amino acid residues, which play important roles in protein function, are often conserved. Here, we analyze thermodynamic and structural data of protein–DNA interactions to explore a relationship between free energy, sequence conservation and structural cooperativity. We observe that the most stabili...

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Detalles Bibliográficos
Main Authors: Ahmad, Shandar, Keskin, Ozlem, Sarai, Akinori, Nussinov, Ruth
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2008
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2566867/
https://ncbi.nlm.nih.gov/pubmed/18801847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn573
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