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Global Sequencing of Proteolytic Cleavage Sites in Apoptosis by Specific Labeling of Protein N-termini

The nearly 600 proteases in the human genome regulate a diversity of biological processes, including programmed cell death. Comprehensive characterization of protease signaling in complex biological samples is limited by available proteomic methods. We have developed a general approach for global id...

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Main Authors: Mahrus, Sami, Trinidad, Jonathan C., Barkan, David T., Sali, Andrej, Burlingame, Alma L., Wells, James A.
Format: Artigo
Jezik:Inglês
Izdano: 2008
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2566540/
https://ncbi.nlm.nih.gov/pubmed/18722006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.08.012
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