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An α-Helical Peptidomimetic Inhibitor of the HIV-1 Rev-RRE Interaction

The interaction between the HIV-1 Rev protein and the Rev-Responsive Element (RRE) RNA is an attractive target for anti-viral therapy. We have designed α-helical peptidomimetics of Rev-like peptides using sidechain-sidechain macrolactam formation between positions i and i+4. One peptidomimetic havin...

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Autori principali: Mills, Nicholas L., Daugherty, Matthew D., Frankel, Alan D., Guy, R. Kiplin
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2566309/
https://ncbi.nlm.nih.gov/pubmed/16536504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja0582051
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