Impaired Hepatitis C Virus (HCV)-Specific Effector CD8(+) T Cells Undergo Massive Apoptosis in the Peripheral Blood during Acute HCV Infection and in the Liver during the Chronic Phase of Infection

A majority of patients infected with hepatitis C virus (HCV) do not sustain an effective T-cell response, and viremia persists. The mechanism leading to failure of the HCV-specific CD8(+) T-cell response in patients developing chronic infection is unclear. We investigated apoptosis susceptibility of...

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Autores principales: Radziewicz, Henry, Ibegbu, Chris C., Hon, Huiming, Osborn, Melissa K., Obideen, Kamil, Wehbi, Mohammad, Freeman, Gordon J., Lennox, Jeffrey L., Workowski, Kimberly A., Hanson, Holly L., Grakoui, Arash
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2008
Materias:
Pathogenesis and Immunity
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2566282/
https://ncbi.nlm.nih.gov/pubmed/18667503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01075-08
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