Cell Cycle-Independent Expression of Immediate-Early Gene 3 Results in G(1) and G(2) Arrest in Murine Cytomegalovirus-Infected Cells

The infectious cycle of human cytomegalovirus (HCMV) is intricately linked to the host's cell cycle. Viral gene expression can be initiated only in G(0)/G(1) phase. Once expressed, the immediate-early gene product IE2 prevents cellular DNA synthesis, arresting infected cells with a G(1) DNA con...

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Hlavní autoři: Wiebusch, Lüder, Neuwirth, Anke, Grabenhenrich, Linus, Voigt, Sebastian, Hagemeier, Christian
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2008
Témata:
Cellular Response to Infection
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2566281/
https://ncbi.nlm.nih.gov/pubmed/18667506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01212-08
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