Fas-Mediated Apoptosis Regulates the Composition of Peripheral αβ T Cell Repertoire by Constitutively Purging Out Double Negative T Cells

BACKGROUND: The Fas pathway is a major regulator of T cell homeostasis, however, the T cell population that is controlled by the Fas pathway in vivo is poorly defined. Although CD4 and CD8 single positive (SP) T cells are the two major T cell subsets in the periphery of wild type mice, the repertoir...

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Main Authors: Mohamood, Abdiaziz S., Bargatze, Dylan, Xiao, Zuoxiang, Jie, Chunfa, Yagita, Hideo, Ruben, Dawn, Watson, Julie, Chakravarti, Shukti, Schneck, Jonathan P., Hamad, Abdel Rahim A.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2008
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2565807/
https://ncbi.nlm.nih.gov/pubmed/18941614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003465
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