Protection from Autoimmune Diabetes and T-Cell Lymphoproliferation Induced by FasL Mutation Are Differentially Regulated and Can Be Uncoupled Pharmacologically

Spontaneous mutation of Fas (lpr) or FasL (gld) completely protects nonobese diabetic mice from autoimmune diabetes but also causes massive double-negative T-cell lymphoproliferation. In this study, we used bone marrow chimeras and adoptive transfer analysis to investigate further the role of FasL i...

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Detalhes bibliográficos
Main Authors: Mohamood, Abdiaziz S., Guler, Mehmet L., Xiao, Zuoxiang, Zheng, Dongfeng, Hess, Allan, Wang, Yi, Yagita, Hideo, Schneck, Jonathan P., Hamad, Abdel Rahim A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2007
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1941609/
https://ncbi.nlm.nih.gov/pubmed/17591957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2007.070148
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