Protection from Autoimmune Diabetes and T-Cell Lymphoproliferation Induced by FasL Mutation Are Differentially Regulated and Can Be Uncoupled Pharmacologically

Spontaneous mutation of Fas (lpr) or FasL (gld) completely protects nonobese diabetic mice from autoimmune diabetes but also causes massive double-negative T-cell lymphoproliferation. In this study, we used bone marrow chimeras and adoptive transfer analysis to investigate further the role of FasL i...

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Hauptverfasser: Mohamood, Abdiaziz S., Guler, Mehmet L., Xiao, Zuoxiang, Zheng, Dongfeng, Hess, Allan, Wang, Yi, Yagita, Hideo, Schneck, Jonathan P., Hamad, Abdel Rahim A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 2007
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Regular Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1941609/
https://ncbi.nlm.nih.gov/pubmed/17591957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2007.070148
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